In real-life, the E80 branches off from the A24 to reach the city of Pescara more directly. From Pescara, travelers would take a ferry to the town of Dubrovnik in Croatia to continue moving along the E80.
After reaching Bijelo Polje, the E80 in real-life diverges from the roads rendered in-game, briefly entering Serbia before pivoting south into Kosovo and reaching the city of Prishtinë.