Due to unrendered roads, the E15 is split into several different sections.
In real-life, the E15 begins in Scotland at the city of Inverness, but since it is outside of the playable area, the E15 starts in-game at the city of Edinburgh.
In real-life, the A1M directly connects Edinburgh with the next major city along the E15, Newcastle-upon-Tyne, but this section is not rendered in-game.
In real-life, the E15 continues south along the A1M, passing through London and terminating at Folkestone, but the majority of this section is unrendered in-game. From there, the route jumps across the English Channel to Calais, and continues south to Paris, but the route follows unrendered or unsigned roads in-game.