In real-life, a ferry carries travelers from Barcelona to Mazara del Vallo in Italy, but this is not included in-game, with the closeest equivalent being the ferry to Palermo.
In real-life, the route continues onto the Italian mainland via the ferry to Villa San Giovanni, but instead follows roads leading down the southern coast if Italy rather than following the A2 north. The E90 is not rendered until further north with the .
In real-life, the E90 continues further southeast to the Italian city of Brindisi, where a ferry then leads to Greece. From there, the route continues across northern Greece and through Turkey.