With only the Italia DLC, Genova can only be accessed from the east. After crossing the Polcevera Viaduct (colloquially referred to as the Ponte Morandi), the A7 goes north towards Milano while the A12 goes southeast towards Livorno and Roma.
If the trucker also has the Vive la France! DLC enabled, then Genova can also be accessed from the west. The A6 goes northwest towards Torino; while the A10 itself ends at the border between France and Italy – the nearest French city is Nice.
Events
On 14 August 2018, the real-life bridge connecting east and west Genova collapsed. The bridge (colloquially known as Ponte Morandi) itself was rendered in the Italia DLC at its release in December 2017, only eight months earlier.
The Ponte Morandi stayed in the game until 4 June 2020, when an event called Operation Genoa Bridge started (parallel to the real-life reconstruction). The bridge was removed, and construction sites on each end appeared. The new bridge, now called the Saint George Viaduct, was added to the game at the end of the event.
Trivia
Genova is "accessible" with neither Italia or Vive le France DLCs. Teleport with cheat to Torino, exit through the southern road and in the interchange go straight bypassing the dual XXXXXX barriers. Once you get off-limits look at the motorway signs when present and go where it says GENOVA, until you see a large white sign with the city name.
Twin-cities of Genova, which are also in SCS Software games: