There are five Interstate Highways in Oklahoma:
| Interstate 35 | Interstate 40 | Interstate 44 | Interstate 235 | Interstate 244 |
|---|---|---|---|---|
 Texas - US 64/US 412 |
 Texas - Sallisaw (US 59) |
 Texas - Oklahoma City (I-40); Oklahoma City (I-35) - Tulsa (US 412) |
 Oklahoma City (I-35/I-40) |
 Tulsa |
There are two inaccessible US Highways in Oklahoma:
There is one US Highway mislabeling a different type of highway in Oklahoma. They are considered errors that are solely route marker mix-ups in real life and are found in the game files. Any in-game bugs related to these errors are not listed:
| SH-1 | SH-3 | SH-7 | SH-8 | SH-9 |
|---|---|---|---|---|
 McAlester |
 Colorado (US 287/US 385) - US 270; Oklahoma City; Broken Bow (US 70/US 259) - Idabel (US 70/US 259) |
 Lawton (I-44/US 277/US 281) - Duncan (US 81) |
 US 412/US 60 |
 Sunset Corner |
| SH-15 | SH-31 | SH-34 | SH-66 | SH-99 |
 Woodward |
 McAlester |
 Woodward |
 Tulsa (I-44/I-244/US 75) - I-44/US 412 |
 I-40/US 377 - Prague (US 62/US 377); Stroud (I-44) - Cushing; US 412/US 64 |
| SH-136 | SH-142 | SH-259A | SH-375 | |
 Guymon |
 Ardmore |
 US 259 - Hochatown (US 259) |
 Hugo (US 70/US 271) - Henryetta (I-40/US 62/US 75) |
There are six inaccessible Oklahoma State Highways:
| SH-5 | SH-37 | SH-95 |
|---|---|---|
 I-44/US 277/US 281 |
 Idabel (US 70) |
 Texhoma (US 54) |
| SH-199 | SH-325 | SH-364 |
 Ardmore (SH-142); Madill (US 70) |
 Boise City (US 56/US 64/US 385/US 412/SH-3) |
 I-44/US 412/SH-66 |
There are three Oklahoma State Highways mislabeling a different type of highway. They are considered errors that are solely route marker mix-ups in real life and are found in the game files. Any in-game bugs related to these errors are not listed:
